The Noyes Lab started at the NYU School of Medicine in the summer of 2015. We are interested in how proteins interact with their targets from structural, computational and cell biology perspectives. As such, our primary goals involve developing new tools to sample these interactions as comprehensively as possible. Our research could be classified as Systems or Synthetic Biology but we hope not to lose sight of the Cell Biology that this is all predicated upon.
I also like to think we are a fun group of people with a diverse set of interests, both in and out of the lab. My hope is that we are creating an enthusiastic, energetic, and friendly atmosphere; and that the Noyes lab becomes known as a special environment to train young scientists for the careers they desire.
**a special thanks to April Mueller for making the awesome Noyes Lab logo above!
David Ichikawa’s first paper was published in ACS Synthetic Biology!
***Funded Graduate Student and Postdoctoral positions available. Please feel free to contact me directly.
Here are some potential rotation projects:
- PDZ domains interact with the C-terminus of their protein binding partners. The domains in prokaryotes have been largely overlooked even though there are more PDZs in the human microbiome than there are in the human genome! We would like to characterize the interacting partners of these domains to predict what regulatory pathways they are associated with and how that impacts the homeostasis of the microbiome.
- Engineering PDZ domains with novel peptide specificity to create artificial signaling pathways
- Investigate how variation across the human proteome, and/or within disease samples, influence the interaction partners of transcription factors
-Develop artificial regulators with novel effector domains fused to Cas9, zinc fingers, or other targeting domains
-Zinc fingers are the most common DNA-binding domain in metazoans and we loosely understand how they interact with DNA, but how do they interact with each other? Investigate how the residues that DONT contact the DNA influence function of adjacent domains.
-many, many more possibilities!
Bio, Marcus Noyes PhD
Dr. Marcus Noyes joined the NYU Institute for Systems Genetic and the Department of Biochemistry and Molecular Pharmacology in July of 2015. Dr. Noyes received his PhD from the University of Massachusetts Medical School where he developed tools for the high-throughput characterization of protein-DNA interactions. He was next recruited as an independent Lewis-Sigler Fellow at Princeton University where he ran a small lab for 5 years before accepting his current position at NYU. His research rests on the edge of Systems and Synthetic Biology, focusing on the development of tools that allow us to understand the binding potential of common protein domains important for biological functions. Using comprehensive, synthetic screens of these protein domains, the goal of his research is to understand the complete functional capacity of a protein and not be limited by the sometimes small set of functions that have evolved. This approach has the added benefit of producing new proteins with novel functions that can be applied to therapeutic applications such as artificial regulation, protein inhibition and precise genome editing.